Acute generalized exanthematous pustulosis upon ingestion of a progesterone preparation.

Sir, In 1968, Baker & Ryan. reported 5 patients with an exanthematic subtype of generalized pustular psoriasis (GPP) (1). The patients had developed a widespread and short-lived sterile pustular eruption either following an infection or for no apparent reason. They had no previous history of psoriasis. In 1980, Beylot et al. (2) introduced the term acute generalized exanthematous pustulosis (AGEP) for the conditions similar or probably identical to an exanthematic type of GPP. Since then, there have been many cases describing similar eruptions as pustular drug rashes or as toxic pustuloderma and considered as a new form of adverse drug reaction (3). We report a patient with AGEP without a previous psoriasis history whose condition was probably precipitated by the progesterone preparation medroxyprogesterone acetate.